178 papers
This study from the COORDINATE-MDD consortium reveals that medication-free major depressive disorder is associated with age-dependent accelerated structural brain aging, which is most pronounced in older adults and linked to specific neuroanatomical phenotypes characterized by worse clinical outcomes.
Through a qualitative Grounded Theory study of 26 participants, this paper proposes a comprehensive five-stage dynamic model of experiential acceptance during anxiety that progresses from interoceptive observation to staying with the experience, thereby clarifying the active mechanisms underlying this emotion regulation process to inform future clinical interventions.
This study demonstrates that a privacy-preserving digital journaling platform not only offers modest clinical benefits for anxiety but also enables scalable, real-time monitoring of behavioral phenotypes and risk patterns, revealing key temporal dynamics such as higher risk in younger users and during late-night hours.
This study demonstrates that individuals at clinical high-risk for psychosis exhibit altered negative associations between corticolimbic glutamatergic metabolite levels and functional connectivity, a disruption not observed in healthy controls despite normal metabolite concentrations.
This study introduces a spatial autocorrelation framework to reveal that the autistic cortex exhibits distinct mesoscale heterogeneity in EEG excitability markers, a topographical pattern that outperforms conventional averaging methods in predicting autism spectrum conditions and is supported by stronger structure-function coupling in macroanatomy.
This study demonstrates that children with Specific Learning Disorder-Reading in the Malayalam alphasyllabary exhibit core phonemic awareness deficits that are most pronounced in linguistically complex tasks lacking lexical support, such as pseudoword blending, and show a distinct lack of age-related improvement compared to typically developing peers.
This study reveals that the Adult ADHD Self-Report Scale (ASRS) exhibits significant differential item functioning across the adult lifespan, with older adults showing reduced endorsement of hyperactivity symptoms but increased endorsement of inattention symptoms, suggesting that current screening practices may systematically underestimate ADHD severity in older populations and highlighting the need for age-adjusted norms or the use of the full 18-item scale.
This study reveals that while autonomic arousal levels are similar across groups, the coupling between arousal and brain network switching—which predicts attentional performance in healthy individuals—is disrupted in schizophrenia spectrum disorders, and network switching rates specifically differentiate these patients from psychiatric controls.
This longitudinal study of the Dutch NeuroIMAGE cohort reveals that while ADHD symptoms are cross-sectionally associated with reduced brain surface area and subcortical volumes, clinical improvement into adulthood coincides with accelerated neural refinement, characterized by more pronounced cortical thinning and surface area reduction in prefrontal and occipital regions.
This study identifies that increased risk-taking in suicidal adolescents is driven by specific computational mechanisms, namely an elevated approach-avoidance parameter and reduced mood sensitivity to certain rewards, which together provide a predictive affective account of suicidal symptom severity.
In a Phase 2 randomized trial, a voice-based AI coach delivering problem-solving treatment significantly improved depression, anxiety, and functional outcomes compared to a waitlist control and showed comparable efficacy to human coaching, despite failing to produce significant changes in the primary neural target of right dorsolateral prefrontal cortex activation.
This study of 142,688 UK Biobank participants reveals that chronic pain is strongly associated with increased prevalence and severity of all depressive symptoms, driven by shared genetic factors and bidirectional causal relationships, particularly involving anhedonia.
This systematic review and meta-analysis of 40 studies reveals that patients with schizoaffective disorder exhibit specific polysomnographic abnormalities, including reduced total sleep time, increased sleep latency and wakefulness, and altered REM and stage 4 sleep parameters compared to healthy controls, while showing sleep patterns largely similar to schizophrenia and only minor differences from depression.
This study demonstrates that personalized connectivity-guided accelerated TMS (TAO-TMS) achieves a 70% response rate in a naturalistic Asian population with treatment-resistant depression and high comorbidity, offering a cost-effective and more comfortable alternative to electroconvulsive therapy while showing superior efficacy compared to standard non-accelerated protocols.
By integrating nationwide real-world clinical data with common and rare genetic variants in a large Danish cohort, this study employs deep learning to stratify schizophrenia spectrum disorder into ten distinct subgroups, revealing unique clinical profiles and specific genetic liabilities that advance biologically informed patient classification.
This study demonstrates that open-weight large language models can accurately extract clinically meaningful information from clinical interview transcripts to assess psychosis risk, offering a scalable and reliable tool to support early detection and preventive care.
This cross-sectional study of 71,214 UK Biobank participants reveals that individuals with co-occurring chronic pain and depression exhibit a distinct and widespread neuroanatomical profile, including reduced cortical volume, specific subcortical atrophy, and white matter microstructure alterations, which differs from the brain structural changes observed in either condition alone.
This population-based study in Ontario reveals that child and youth mental health symptoms remained elevated during pandemic lockdowns but significantly improved as restrictions eased, with notable variations by symptom type, gender, and pre-existing conditions, highlighting the need for equity-informed policies that balance viral control with the minimization of lockdown impacts.
This study demonstrates that functional connectivity patterns predicting sustained attention and autism symptoms are phenotype-specific and vary significantly based on participant age and clinical diagnosis, highlighting the importance of considering these factors in transdiagnostic connectome-based models.
This protocol outlines a parallel population-based target trial emulation study using linked health administrative data from British Columbia and Ontario (2010–2023) to compare the effectiveness of various pharmacological treatments for bipolar disorder among individuals with concurrent opioid use disorder, with outcomes including psychiatric acute-care visits, treatment discontinuation, and all-cause mortality.